miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

Current and future biomarkers in multiple sclerosis

J Yang, M Hamade, Q Wu, Q Wang, R Axtell… - International journal of …, 2022 - mdpi.com
Multiple sclerosis (MS) is a debilitating autoimmune disorder. Currently, there is a lack of
effective treatment for the progressive form of MS, partly due to insensitive readout for …

MicroRNA-146a: a dominant, negative regulator of the innate immune response

R Saba, DL Sorensen, SA Booth - Frontiers in immunology, 2014 - frontiersin.org
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that can play critical
roles as regulators of numerous pathways and biological processes including the immune …

[HTML][HTML] MicroRNA alteration, application as biomarkers, and therapeutic approaches in neurodegenerative diseases

TPN Nguyen, M Kumar, E Fedele, G Bonanno… - International journal of …, 2022 - mdpi.com
MicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various
neuronal and non-neuronal cell functions and play a key role in pathological conditions …

miR-22 gene therapy treats HCC by promoting anti-tumor immunity and enhancing metabolism

Y Hu, T Setayesh, F Vaziri, X Wu, ST Hwang, X Chen… - Molecular Therapy, 2023 - cell.com
MicroRNA-22 (miR-22) can be induced by beneficial metabolites that have metabolic and
immune effects, including retinoic acids, bile acids, vitamin D 3, and short-chain fatty acids …

MicroRNA-21 is a versatile regulator and potential treatment target in central nervous system disorders

X Bai, Z Bian - Frontiers in molecular neuroscience, 2022 - frontiersin.org
MicroRNAs (miRNAs) are a class of endogenous, non-coding, single-stranded RNAs with a
length of approximately 22 nucleotides that are found in eukaryotes. miRNAs are involved in …

Plasma miR-34a-5p and miR-545-3p as early biomarkers of Alzheimer's disease: potential and limitations

M Cosín-Tomás, A Antonell, A Lladó, D Alcolea… - Molecular …, 2017 - Springer
Plasma microRNAs (miRNAs) have been proposed as potential biomarkers in Alzheimer's
disease (AD). Here, we explored their use as early sensors of the preclinical phase of the …

[HTML][HTML] microRNA diagnostic panel for Alzheimer's disease and epigenetic trade-off between neurodegeneration and cancer

S Nagaraj, KM Zoltowska, K Laskowska-Kaszub… - Ageing research …, 2019 - Elsevier
Abstract microRNAs (miRNAs) have been extensively studied as potential biomarkers for
Alzheimer's disease (AD). Their profiles have been analyzed in blood, cerebrospinal fluid …

Impaired oligodendrocyte maturation in preterm infants: Potential therapeutic targets

E Van Tilborg, CJ Heijnen, MJ Benders, F van Bel… - Progress in …, 2016 - Elsevier
Preterm birth is an evolving challenge in neonatal health care. Despite declining mortality
rates among extremely premature neonates, morbidity rates remain very high. Currently …

The role of miRNAs in multiple sclerosis pathogenesis, diagnosis, and therapeutic resistance

AS Doghish, O Elazazy, HH Mohamed… - … -Research and Practice, 2023 - Elsevier
In recent years, microRNAs (miRNAs) have gained increased attention from researchers
around the globe. Although it is twenty nucleotides long, it can modulate several gene …