Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

C Ma, MD Sacco, B Hurst, JA Townsend, Y Hu, T Szeto… - Cell research, 2020 - nature.com
A new coronavirus SARS-CoV-2, also called novel coronavirus 2019 (2019-nCoV), started
to circulate among humans around December 2019, and it is now widespread as a global …

Dopamine reduction in the substantia nigra of Parkinson's disease patients confirmed by in vivo magnetic resonance spectroscopic imaging

A Gröger, R Kolb, R Schäfer, U Klose - PloS one, 2014 - journals.plos.org
Objectives Metabolic changes in the substantia nigra of patients with Parkinson's disease
were previously investigated in different molecular-pathological examinations. The aim of …

Thalamic involvement in fluctuating cognition in dementia with Lewy bodies: magnetic resonance evidences

S Delli Pizzi, R Franciotti, JP Taylor, A Thomas… - Cerebral …, 2015 - academic.oup.com
Dementia with Lewy bodies (DLB) is characterized by fluctuation in cognition and attention.
Thalamocortical connectivity and integrity of thalami are central to attentional function. We …

Preclinical magnetic resonance imaging and spectroscopy studies of memory, aging, and cognitive decline

M Febo, TC Foster - Frontiers in aging neuroscience, 2016 - frontiersin.org
Neuroimaging provides for non-invasive evaluation of brain structure and activity and has
been employed to suggest possible mechanisms for cognitive aging in humans. However …

GABA content within the ventromedial prefrontal cortex is related to trait anxiety

S Delli Pizzi, C Padulo, A Brancucci… - Social cognitive and …, 2016 - academic.oup.com
The ventromedial prefrontal cortex (vmPFC) plays a key role in emotion processing and
regulation. vmPFC dysfunction may lead to disinhibition of amygdala causing high anxiety …

Modeling nigrostriatal degeneration in organotypic cultures, a new ex vivo model of Parkinson's disease

N Daviaud, E Garbayo, N Lautram, F Franconi… - Neuroscience, 2014 - Elsevier
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder afflicting
2% of the population older than 65 years worldwide. Recently, brain organotypic slices have …

High γ‐aminobutyric acid content within the medial prefrontal cortex is a functional signature of somatic symptoms disorder in patients with Parkinson's disease

S Delli Pizzi, R Franciotti, A Ferretti… - Movement …, 2020 - Wiley Online Library
Background The dysfunctional activity of the medial prefrontal cortex has been associated
with the appearance of the somatic symptom disorder, a key feature of the Parkinson's …

Detecting dopaminergic neuronal degeneration using diffusion tensor imaging in a rotenone-induced rat model of Parkinson's disease: fractional anisotropy and mean …

L Liu, D Du, T Zheng, Y Fang, Y Chen… - Neural regeneration …, 2017 - journals.lww.com
Dopamine content in the basal ganglia is strongly associated with the degree of
dopaminergic neuron loss in the substantia nigra pars compacta. Symptoms of Parkinson's …

Metabolic disturbances in the striatum and substantia nigra in the onset and progression of MPTP-induced Parkinsonism model

Y Lu, X Zhang, L Zhao, C Yang, L Pan, C Li… - Frontiers in …, 2018 - frontiersin.org
Metabolic confusion has been linked to the pathogenesis of Parkinson's disease (PD), while
the dynamic changes associated with the onset and progression of PD remain unclear …

Safety and effects on motor cortex excitability of five cathodal transcranial direct current stimulation sessions in 25 hours

F Zappasodi, G Musumeci, R Navarra… - Neurophysiologie …, 2018 - Elsevier
Objective To assess the safety and effects on motor cortex excitability of five cathodal-tDCS
sessions (charge density 342.9 C/m 2) delivered over the dominant motor cortex with a …