One of the relevant problems in today's agriculture is related to phytopathogenic
microorganisms that cause between 30–40% of crop losses. Synthetic chemical pesticides …

Actinomycetes continue to be important sources for the discovery of secondary metabolites
for applications in human medicine, animal health, and crop protection. With the maturation …

Volatile compounds emitted by bacteria are often sensed by other organisms as odours, but
their ecological roles are poorly understood,. Well-known examples are the soil-smelling …

The widespread use of antibiotics has placed bacterial pathogens under intense pressure to
evolve new survival mechanisms. Genomic analysis of 51,229 Mycobacterium tuberculosis …

The cyclic dinucleotide c-di-GMP is a signaling molecule with diverse functions in cellular
physiology. Here, we report that c-di-GMP can assemble into a tetramer that mediates the …

Highlights•A rational optimization of Streptomyces strains is possible.•This can be achieved
through rewiring of primary metabolism and regulatory networks.•Biosynthetic gene cluster …

The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the
growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate …

Streptomyces are Gram-positive microorganisms able to adapt and respond to different
environmental conditions. It is the largest genus of Actinobacteria comprising over 900 …

Studies of transcriptional initiation in different bacterial clades reveal diverse molecular
mechanisms regulating this first step in gene expression. The WhiA and WhiB factors are …

Mycobacterium tuberculosis possesses a large number of genes of unknown or predicted
function, undermining fundamental understanding of pathogenicity and drug susceptibility …