The role of non-coding RNAs in oncology
FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
Personalized medicine: motivation, challenges, and progress
LH Goetz, NJ Schork - Fertility and sterility, 2018 - Elsevier
There is a great deal of hype surrounding the concept of personalized medicine.
Personalized medicine is rooted in the belief that since individuals possess nuanced and …
Personalized medicine is rooted in the belief that since individuals possess nuanced and …
The emerging role of the piRNA/piwi complex in cancer
Y Liu, M Dou, X Song, Y Dong, S Liu, H Liu, J Tao, W Li… - Molecular cancer, 2019 - Springer
Piwi interacting RNAs (piRNAs) constitute novel small non-coding RNA molecules of
approximately 24–31 nucleotides in length that often bind to members of the piwi protein …
approximately 24–31 nucleotides in length that often bind to members of the piwi protein …
The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non‐coding RNA and synonymous mutations
S Diederichs, L Bartsch, JC Berkmann… - EMBO molecular …, 2016 - embopress.org
Cancer is a disease of the genome caused by oncogene activation and tumor suppressor
gene inhibition. Deep sequencing studies including large consortia such as TCGA and …
gene inhibition. Deep sequencing studies including large consortia such as TCGA and …
SPRDA: a link prediction approach based on the structural perturbation to infer disease-associated Piwi-interacting RNAs
Abstract piRNA and PIWI proteins have been confirmed for disease diagnosis and treatment
as novel biomarkers due to its abnormal expression in various cancers. However, the …
as novel biomarkers due to its abnormal expression in various cancers. However, the …
PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA
L Tan, D Mai, B Zhang, X Jiang, J Zhang, R Bai, Y Ye… - Molecular cancer, 2019 - Springer
Background Breast cancer is one of the most common malignancies and the major cause of
cancer-related death in women. Although the importance of PIWI-interacting RNAs (piRNAs) …
cancer-related death in women. Although the importance of PIWI-interacting RNAs (piRNAs) …
[HTML][HTML] PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma
D Mai, P Ding, L Tan, J Zhang, Z Pan, R Bai, C Li… - Theranostics, 2018 - ncbi.nlm.nih.gov
Abstract Although PIWI-interacting RNAs (piRNAs) have recently been linked to human
diseases, their roles and functions in malignancies remain unclear. This study aimed to …
diseases, their roles and functions in malignancies remain unclear. This study aimed to …
The biogenesis and functions of piRNAs in human diseases
X Wu, Y Pan, Y Fang, J Zhang, M **e, F Yang… - … Therapy-Nucleic Acids, 2020 - cell.com
Piwi-interacting RNAs (piRNAs) are a novel type of small noncoding RNAs, which are 26–30
nt in length and bind to Piwi proteins. These short RNAs were originally discovered in …
nt in length and bind to Piwi proteins. These short RNAs were originally discovered in …
Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation
L Ai, S Mu, C Sun, F Fan, H Yan, Y Qin, G Cui, Y Wang… - Molecular Cancer, 2019 - Springer
Background Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are
two important cellular components in the tumor microenvironment, which may modify the …
two important cellular components in the tumor microenvironment, which may modify the …
The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
Transposable elements (TEs) contribute to the large amount of repetitive sequences in
mammalian genomes and have been linked to species-specific genome innovations by …
mammalian genomes and have been linked to species-specific genome innovations by …