Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

We have explored the fundamental biological processes by which complex carbohydrates
expressed on cellular glycoproteins and glycolipids and in secretions of cells promote cell …

The success of investigations on the structure and function of the genome (genomics) has
been paralleled by an equally awesome progress in the analysis of protein structure and …

Polymeric sialic acid (polysialic acid, polySia) is a remarkable posttranslational modification
of only few select proteins. The major, and most prominent polySia protein carrier is the …

In mammals several cell adhesion molecules are involved during the pre-and postnatal
development of all organ systems. A very prominent member of this family is the neural cell …

Polysialic acid (polySia), a homopolymer of α2, 8-linked sialic acid residues, modifies a
small number of proteins and has central functions in vertebrate signalling. Here, we review …

The overexpression of polysialic acid (polySia) on neural cell adhesion molecules (NCAM)
promotes hypersialylation, and thus benefits cancer cell migration and invasion. It has been …

Polysialylation is a process of polysialic acid (polySia) addition to neural cell adhesion
molecule (NCAM), which is associated with tumor cell migration and progression in many …

Polysialic acid (polySia) is an unusual glycan that posttranslational modifies neural cell
adhesion molecule (NCAM) proteins in mammalian cells. The up-regulated expression of …

Background: The polysialic acid (polySia) is a unique carbohydrate polymer produced on
the surface Of Neuronal Cell Adhesion Molecule (NCAM) in a number of cancer cells, and …