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The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
J Yang, J Xu, W Wang, B Zhang, X Yu… - Signal transduction and …, 2023 - nature.com
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
[HTML][HTML] Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells
J ** the tumor
microenvironment (TME), the mechanisms by which TAMs influence the TME and contribute …
microenvironment (TME), the mechanisms by which TAMs influence the TME and contribute …
Targeting the RNA m6A modification for cancer immunotherapy
Abstract N 6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA,
and its dysregulation drives aberrant transcription and translation programs that promote …
and its dysregulation drives aberrant transcription and translation programs that promote …
FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development
N 6-methyladenosine (m6A) is the most abundant internal modification on mammalian
messenger RNA. It is installed by a writer complex and can be reversed by erasers such as …
messenger RNA. It is installed by a writer complex and can be reversed by erasers such as …
Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration
Repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD). Here we show that N 6 …
sclerosis (ALS) and frontotemporal dementia (FTD). Here we show that N 6 …