[HTML][HTML] Anything but ordinary–emerging splicing mechanisms in eukaryotic gene regulation
NH Gehring, JY Roignant - Trends in Genetics, 2021 - cell.com
Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene
expression. The identification of the actual splice sites and the proper removal of introns are …
expression. The identification of the actual splice sites and the proper removal of introns are …
Cryo-EM snapshots of the human spliceosome reveal structural adaptions for splicing regulation
SM Fica - Current opinion in structural biology, 2020 - Elsevier
Highlights•Cryo-EM structures reveal a more complex proteome for the human spliceosome
compared to budding yeast.•Movements of three loop-like elements of the core protein Prp8 …
compared to budding yeast.•Movements of three loop-like elements of the core protein Prp8 …
Retained introns in long RNA-seq reads are not reliably detected in sample-matched short reads
Background There is growing interest in retained introns in a variety of disease contexts
including cancer and aging. Many software tools have been developed to detect retained …
including cancer and aging. Many software tools have been developed to detect retained …
Transcription and splicing dynamics during early Drosophila development
Widespread cotranscriptional splicing has been demonstrated from yeast to human.
However, most studies to date addressing the kinetics of splicing relative to transcription …
However, most studies to date addressing the kinetics of splicing relative to transcription …
Two-pass alignment using machine-learning-filtered splice junctions increases the accuracy of intron detection in long-read RNA sequencing
Transcription of eukaryotic genomes involves complex alternative processing of RNAs.
Sequencing of full-length RNAs using long-reads reveals the true complexity of processing …
Sequencing of full-length RNAs using long-reads reveals the true complexity of processing …
Proofreading and Progression at the Catalytic Stages of Splicing: Novel Insights into the Roles and Regulation of Deah-Box ATPases
CAJ Craddock - 2022 - search.proquest.com
Pre-mRNA splicing is an essential step in eukaryotic gene expression, wherein interrupting
sequences (“introns”) are excised from newly transcribed precursor messenger RNA (pre …
sequences (“introns”) are excised from newly transcribed precursor messenger RNA (pre …