Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …

Successful drug discovery is like finding oases of safety and efficacy in chemical and
biological deserts. Screens in disease models, and other decision tools used in drug …

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …

Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …

There is widespread concern about the quality, reproducibility and translatability of studies
involving research animals. Although there are a number of reporting guidelines available …

Introduction: Some cannabinoids have been identified as anti-inflammatory agents;
however, their potential therapeutic or prophylactic applications remain controversial. The …

Background Over 120 million mice and rats are used annually in research, conventionally
housed in shoebox-sized cages that restrict natural behaviours (eg nesting and burrowing) …

There has been a revolution within clinical trials to include females in the research pipeline.
However, there has been limited change in the preclinical arena; yet the research here lays …

FIGURE 1| Refined procedure for harm-benefit-analysis (HBA) in animal research. Whereas
3Rs methods minimize the weight of harms to the animals on the HBA balance, methods to …

There are important scientific, legal and ethical reasons for optimising the quality of animal
research and testing. Concerns about the reproducibility and translatability of animal studies …