This review summarizes what is known about the biochemical and biophysical mechanisms
that initiate the assembly of actin filaments in cells. Assembly and disassembly of these …

Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …

Endocytosis includes a number of processes by which cells internalize segments of their
plasma membrane, enclosing a wide variety of material from outside the cell. Endocytosis …

All cells undergo rapid remodeling of their actin networks to regulate such critical processes
as endocytosis, cytokinesis, cell polarity, and cell morphogenesis. These events are driven …

The establishment of cell polarity is critical for the development of many organisms and for
the function of many cell types. A large number of studies of diverse organisms from yeast to …

Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is
essential for bringing many substances into the cell and for membrane turnover. The …

BAR and ENTH domains are families of α-helical lipid bilayer binding modules found in
proteins that function in endocytosis, actin regulation and signaling. Several members of …

Actin polymerization essential for endocytic internalization in budding yeast is controlled by
four nucleation promoting factors (NPFs) that each exhibits a unique dynamic behavior at …

The actin cytoskeleton is indispensable for several cellular processes, including migration,
morphogenesis, polarized growth, endocytosis, and phagocytosis. The organization and …

Key steps in regulating actin dynamics are the de novo nucleation and elongation of actin
filaments, which can be catalysed by a limited number of proteins and protein complexes …