We have analyzed FDA-approved macrocyclic drugs, clinical candidates, and the recent
literature to understand how macrocycles are used in drug discovery. Current drugs are …

In contrast to the major families of small molecules and antibodies, cyclic peptides, as a
family of synthesizable macromolecules, have distinct biochemical and therapeutic …

This review covers the literature published in 2019 for marine natural products (MNPs), with
719 citations (701 for the period January to December 2019) referring to compounds …

Cyclic peptides are promising scaffolds for drug development, attributable in part to their
increased conformational order compared to linear peptides. However, when optimizing the …

Fluoride, as the smallest anion except hydride (H–), has garnered considerable attention
over the past decades due to its specific physiochemical properties and its crucial roles in …

Molecular chameleons possess a flexibility that allows them to dynamically shield or expose
polar functionalities in response to the properties of the environment. Although the concept …

Programmed cell death receptor 1 (PD-1) and its ligand PD-L1 are particularly interesting
immune checkpoint proteins for human cancer treatment. Positron emission tomography …

Macrocycles fascinate chemists due to both their structure and their applications. However,
we still lack efficient and sustainable synthetic methods, giving us straightforward access to …

Three-dimensional conformation is the primary determinant of molecular properties. The
thermal energy available at room temperature typically equilibrates the accessible …

Organic electrode materials could revolutionize batteries because of their high energy
densities, the use of Earth‐abundant elements, and structural diversity which allows fine …