Background To investigate differences in pathogenesis, diagnosis and resistance pathways
between HIV-1 subtypes, an accurate subty** tool for large datasets is needed. We aimed …

Abstract HIV-Associated Neurocognitive Disorders (HAND) exert an impact on everyday
functions, including adherence. The prevalence of and risk factors for HAND in patients …

HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We
aimed to characterize the HIV-1 IN gene in a South African context and identify resistance …

Human immunodeficiency virus type 1 (HIV-1) integrase (IN) integrates viral DNA into the
host genome using its 3′-end processing and strand-transfer activities. Due to the …

Previous studies have reported cognitive deficits among HIV-positive individuals infected
with clade C virus. However, no study has examined whether individuals predominately …

It is not known whether the apolipoprotein E (ApoE) ε4 allelic variant is associated with
human immunodeficiency virus (HIV)-associated dementia (HAD) in a South African …

South Africa has the largest worldwide HIV/AIDS population with 5.6 million people infected
and at least 2 million people on antiretroviral therapy. The majority of these infections are …

Objective: Early studies in Cape Town identified independent HIV-1 epidemics, with distinct
viral subtypes, among men who have sex with men (MSM) and the heterosexual population …

Dysfunction of dopaminergic neurotransmission has been implicated in HIV infection. We
showed previously increased dopamine (DA) levels in CSF of therapy-naïve HIV patients …

Abstract Background South Africa has a generalized and explosive HIV/AIDS epidemic with
the largest number of people infected with HIV-1 in the world. Molecular investigations of …