The distinctive differentiated states of the CD4+ T helper cells are determined by the set of
transcription factors and the genes transcribed by the transcription factors. In vitro induction …

Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …

T cells, a key component of cancer immunotherapy, undergo a variety of histone
modifications and DNA methylation changes since their bone marrow progenitor stages …

T follicular helper (TFH) cells are specialized effector CD4+ T cells critical to humoral
immunity. Whether post-transcriptional regulation has a function in TFH cells is unknown …

Follicular helper T cells (TFH cells) are specialized effector CD4+ T cells that help B cells
develop germinal centers (GCs) and memory. However, the transcription factors that …

Induction of the transcriptional repressor Bcl-6 in CD4+ T cells is critical for the differentiation
of follicular helper T cells (TFH cells), which are essential for B cell–mediated immunity. In …

T follicular helper (Tfh) cells are essential in the induction of high-affinity, class-switched
antibodies. The differentiation of Tfh cells is a multi-step process that depends upon the co …

Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality
after allogeneic hematopoietic stem cell transplantation. Having shown that germinal center …

Despite the increasing knowledge of the molecular events that induce the glycolysis
pathway in effector T cells, very little is known about the transcriptional mechanisms that …

The strong genetic association between particular HLA alleles and type 1 diabetes (T1D)
indicates a key role for CD4+ T cells in disease; however, the differentiation state of the …