Mechanisms underlying dose-limiting toxicities of conventional chemotherapeutic agents

MA Manavi, MH Fathian Nasab… - Journal of …, 2024 - Taylor & Francis
Dose-limiting toxicities (DLTs) are severe adverse effects that define the maximum tolerated
dose of a cancer drug. In addition to the specific mechanisms of each drug, common …

Pharmacological updates of nifuroxazide: promising preclinical effects and the underlying molecular mechanisms

HS Althagafy, MK Abd El-Aziz, IM Ibrahim… - European Journal of …, 2023 - Elsevier
Nifuroxazide (NFX) is a safe nitrofuran antibacterial drug used clinically to treat acute
diarrhea and infectious traveler diarrhea or colitis. Recent studies revealed that NFX …

Unveiling the capability of novel cobalt/barium stannate nanoparticles embedded functionalized MWCNTs nanocomposite for electrochemical investigation of …

C Koventhan, SM Babulal, SM Chen, AY Lo… - Materials Today …, 2024 - Elsevier
Nifuroxazide (NFR) is a class of synthetic broad-spectrum antibiotics and recently was
proven to have anticancer properties, which are widely used to treat infectious diarrhea and …

[HTML][HTML] Mirtazapine, an atypical antidepressant, mitigates lung fibrosis by suppressing NLPR3 inflammasome and fibrosis-related mediators in endotracheal …

R Abdelhady, S Cavalu, S Saber, R Elmowafy… - Biomedicine & …, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease with a poor
prognosis. There is currently no definitive cure for IPF. The present study establishes a …

Pregnancy and COVID-19: high or low risk of vertical transmission

HM Al-Kuraishy, AI Al-Gareeb, NKA Albezrah… - Clinical and …, 2023 - Springer
Abstract Coronavirus disease 19 (COVID-19) is an infectious disease caused by severe
acute respiratory syndrome 2 (SARS-CoV-2). Throughout the pandemic, evidence on the …

Revolutionizing the treatment of idiopathic pulmonary fibrosis: From conventional therapies to advanced drug delivery systems

S Singh, S Wairkar - AAPS PharmSciTech, 2024 - Springer
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease that
has been well-reported in the medical literature. Its incidence has risen, particularly in light …

Nifuroxazide mitigates doxorubicin-induced cardiovascular injury: Insight into oxidative/NLRP3/GSDMD-mediated pyroptotic signaling modulation

FM Amin, MH Sharawy, MN Amin, M El-Sherbiny… - Life sciences, 2023 - Elsevier
Doxorubicin (DOX) is a widely used powerful anthracycline for treatment of many varieties of
malignancies; however its cumulative and dose-dependent cardio-toxicity has been limited …

[HTML][HTML] Pimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6/STAT3/HIF-1α autocrine loop in rats with bleomycin-challenged lungs …

DH El-Kashef, ME Youssef, M Nasr, M Alrouji… - Biomedicine & …, 2022 - Elsevier
Idiopathic pulmonary fibrosis is a fatal lung disorder in which the etiology and pathogenesis
are still unobvious. Effective treatments are urgently needed considering that lung …

Unlocking the potential of nanocarrier-mediated mRNA delivery across diverse biomedical frontiers: A comprehensive review

S Pawar, P **ale, A Garkal, RAM Osmani… - International Journal of …, 2024 - Elsevier
Messenger RNA (mRNA) has gained marvelous attention for managing and preventing
various conditions like cancer, Alzheimer's, infectious diseases, etc. Due to the quick …

Progress and challenges of lyotropic liquid crystalline nanoparticles for innovative therapies

AVP Silvestrini, BW Debiasi, FG Praca… - International Journal of …, 2022 - Elsevier
Since the late 20th century, we have witnessed a growing and substantial advance in
nanomedicine, in part due to the development of multifunctional and multimodal …