Our desire to understand how the individual molecules that make up cells organize, interact,
and communicate to form living systems has led to the burgeoning field of chemical biology …

Blocking the biological functions of scaffold proteins and aggregated proteins is a
challenging goal. PROTAC proteolysis-targeting chimaera (PROTAC) technology may be …

Amide bonds are the most prevalent structures found in organic molecules and various
biomolecules such as peptides, proteins, DNA, and RNA. The unique feature of amide …

Platinum-containing drugs (eg, cisplatin) are among the most frequently used
chemotherapeutic agents. Their tremendous success has spurred research and …

Organometallic complexes are effective hydrogenation catalysts for organic reactions. For
example, Noyori-type ruthenium complexes catalyse reduction of ketones by transfer of …

Highlights•How can metal catalysts be used for biochemical transformations?•Catalysis by
metal complexes can even be achieved in cells.•Catalysis includes C single bond C bond …

Metal-assisted hydrolysis of peptide bond is a promising alternative for enzymatic cleavage
of proteins with prospective applications in biochemistry and bioengineering. Many metal …

Metal complexes that catalyze inactivation and degradation of biomolecular targets can be
developed into novel therapeutics (catalytic metallodrugs) against a variety of diseases …

The hydrolysis of extremely stable peptide and phosphoester bonds by metalloenzymes is of
great interest in biotechnology and industry. However, due to various shortcomings only a …

A series of compounds that target reactive transition-metal chelates to somatic angiotensin
converting enzyme (sACE-1) have been synthesized. Half-maximal inhibitory concentrations …