Genetics of human longevity: From variants to genes to pathways
L Smulders, J Deelen - Journal of Internal Medicine, 2024 - Wiley Online Library
The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …
challenge to the healthcare system and a severe burden on society. However, some …
[HTML][HTML] Mitochondrial and metabolic features of salugenesis and the healing cycle
RK Naviaux - Mitochondrion, 2023 - Elsevier
Pathogenesis and salugenesis are the first and second stages of the two-stage problem of
disease production and health recovery. Salugenesis is the automatic, evolutionarily …
disease production and health recovery. Salugenesis is the automatic, evolutionarily …
[HTML][HTML] Phenotypic molecular features of long-lived animal species
One of the challenges facing science/biology today is uncovering the molecular bases that
support and determine animal and human longevity. Nature, in offering a diversity of animal …
support and determine animal and human longevity. Nature, in offering a diversity of animal …
The elephant evolved p53 isoforms that escape MDM2-mediated repression and cancer
M Padariya, ML Jooste, T Hupp… - Molecular biology …, 2022 - academic.oup.com
The p53 tumor suppressor is a transcription factor with roles in cell development, apoptosis,
oncogenesis, aging, and homeostasis in response to stresses and infections. p53 is tightly …
oncogenesis, aging, and homeostasis in response to stresses and infections. p53 is tightly …
Comparative genomics reveals convergent signals associated with the high metabolism and longevity in birds and bats
Y Matsuda, T Makino - Proceedings of the Royal Society …, 2024 - royalsocietypublishing.org
Birds and bats have long lifespans relative to their body size compared with non-flying
animals. However, the genomic basis associated with longer lifespan of flying species …
animals. However, the genomic basis associated with longer lifespan of flying species …
[HTML][HTML] Investigation of the effects of downregulation of jum** translocation breakpoint (JTB) protein expression in MCF7 cells for potential use as a biomarker in …
MCF7 is a commonly used luminal type A non-invasive/poor-invasive human breast cancer
cell line that does not usually migrate or invade compared with MDA-MB-231 highly …
cell line that does not usually migrate or invade compared with MDA-MB-231 highly …
Lability of the Nrf2/Keap/ARE cell defense system in different models of cell aging and age-related pathologies
GA Shilovsky - Biochemistry (Moscow), 2022 - Springer
The level of oxidative stress in an organism increases with age. Accumulation of damages
resulting in the disruption of genome integrity can be the cause of many age-related …
resulting in the disruption of genome integrity can be the cause of many age-related …
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals
The genetic roots of the diverse paces and shapes of ageing and of the large variations in
longevity observed across the tree of life are poorly understood. Indeed, pathways …
longevity observed across the tree of life are poorly understood. Indeed, pathways …
Duplications of human longevity-associated genes across placental mammals
Natural selection has shaped a wide range of lifespans across mammals, with a few long-
lived species showing negligible signs of ageing. Approaches used to elucidate the genetic …
lived species showing negligible signs of ageing. Approaches used to elucidate the genetic …
The Race between Mortality and Morbidity: Implications for the Global Distribution of Health
Assessments of countries' longevity and its variability around the globe often rely on life
expectancy (LE) but tend not to differentiate between the years spent in “good” or “less‐than …
expectancy (LE) but tend not to differentiate between the years spent in “good” or “less‐than …