ATP-binding cassette (ABC) transporters play a crucial role for the efflux of a wide range of
substrates across different cellular membranes. In the central nervous system (CNS), ABC …

Lenvatinib is a multikinase inhibitor that suppresses vascular endothelial growth factor
receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor …

Background Huntington disease (HD) is a neurodegenerative disorder with complex motor
and behavioural manifestations. The Q175 knock-in mouse model of HD has gained recent …

At the core of complex and multifactorial human diseases, such as cancer, metabolic
syndrome, or neurodegeneration, are multiple players that cross‐talk in robust biological …

Background Mass spectrometry (MS)-based cerebrospinal fluid (CSF) proteomics is an
important method for discovering biomarkers of neurodegenerative diseases. CSF serves as …

Medicinal polypharmacology is one answer to the complex reality of multifactorial human
diseases that are often unresponsive to single-targeted treatment. It is an admittance that …

Alzheimer's disease (AD) is the most common cause of dementia. Fingolimod has previously
shown beneficial effects in different animal models of AD. However, it has shown …

Huntington's disease (HD) is a progressive neurodegenerative disease affecting motor and
cognitive abilities. Multiple studies have found white matter anomalies in HD-affected …

Sven Marcel Stefan*,#, Muhammad Rafehi*,# aspects that need to be met before publication
of an article. However, these standards must not be confounded with general scientific …

Rare diseases may affect the quality of life of patients and be life-threatening. Therapeutic
opportunities are often limited, in part because of the lack of understanding of the molecular …