Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer
Progesterone receptor (PR) mediates the actions of the ovarian steroid progesterone, which
together with estradiol regulates gonadotropin secretion, prepares the endometrium for …
together with estradiol regulates gonadotropin secretion, prepares the endometrium for …
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, conference …
JH Segars, EC Parrott, JD Nagel… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND Uterine fibroids are the most common gynecologic tumors in women of
reproductive age yet the etiology and pathogenesis of these lesions remain poorly …
reproductive age yet the etiology and pathogenesis of these lesions remain poorly …
Nucleosome-driven transcription factor binding and gene regulation
Elucidating the global function of a transcription factor implies the identification of its target
genes and genomic binding sites. The role of chromatin in this context is unclear, but the …
genes and genomic binding sites. The role of chromatin in this context is unclear, but the …
[HTML][HTML] A Gata2-dependent transcription network regulates uterine progesterone responsiveness and endometrial function
Altered progesterone responsiveness leads to female infertility and cancer, but underlying
mechanisms remain unclear. Mice with uterine-specific ablation of GATA binding protein 2 …
mechanisms remain unclear. Mice with uterine-specific ablation of GATA binding protein 2 …
Phosphorylated progesterone receptor isoforms mediate opposing stem cell and proliferative breast cancer cell fates
Progesterone receptors (PRs) are key modifiers of estrogen receptor (ER) target genes and
drivers of luminal breast cancer progression. Total PR expression, rather than isoform …
drivers of luminal breast cancer progression. Total PR expression, rather than isoform …
PDK4 inhibits cardiac pyruvate oxidation in late pregnancy
Rationale: Pregnancy profoundly alters maternal physiology. The heart hypertrophies during
pregnancy, but its metabolic adaptations, are not well understood. Objective: To determine …
pregnancy, but its metabolic adaptations, are not well understood. Objective: To determine …
Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank
I Pardo, HA Lillemoe, RJ Blosser, MR Choi… - Breast Cancer …, 2014 - Springer
Introduction Our efforts to prevent and treat breast cancer are significantly impeded by a lack
of knowledge of the biology and developmental genetics of the normal mammary gland. In …
of knowledge of the biology and developmental genetics of the normal mammary gland. In …
Recreating the female reproductive tract in vitro using iPSC technology in a linked microfluidics environment
The female reproductive tract produces hormones for reproductive function and
cardiovascular, bone and sexual health; the tract supplies a finite number of gametes, and it …
cardiovascular, bone and sexual health; the tract supplies a finite number of gametes, and it …
Gene expression changes in uterine myomas in response to ulipristal acetate treatment
Research question Does ulipristal acetate (UPA) modify the expression of genes related to
apoptosis or the extracellular matrix in uterine myomas and are any modifications …
apoptosis or the extracellular matrix in uterine myomas and are any modifications …