Biosensor regeneration: a review of common techniques and outcomes
Biosensors are ideally portable, low-cost tools for the rapid detection of pathogens, proteins,
and other analytes. The global biosensor market is currently worth over 10 billion dollars …
and other analytes. The global biosensor market is currently worth over 10 billion dollars …
Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics
Therapeutic monoclonal antibodies and their derivatives are key components of clinical
pipelines in the global biopharmaceutical industry. The availability of large datasets of …
pipelines in the global biopharmaceutical industry. The availability of large datasets of …
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
Signaling through the programmed death 1 (PD-1) inhibitory receptor upon binding its
ligand, PD-L1, suppresses immune responses against autoantigens and tumors and plays …
ligand, PD-L1, suppresses immune responses against autoantigens and tumors and plays …
Protein–protein interaction and quaternary structure
Protein–protein recognition plays an essential role in structure and function. Specific non-
covalent interactions stabilize the structure of macromolecular assemblies, exemplified in …
covalent interactions stabilize the structure of macromolecular assemblies, exemplified in …
Free energy simulations come of age: Protein− ligand recognition
T Simonson, G Archontis, M Karplus - Accounts of chemical …, 2002 - ACS Publications
In recent years, molecular dynamics simulations of biomolecular free energy differences
have benefited from significant methodological advances and increased computer power …
have benefited from significant methodological advances and increased computer power …
Molecular recognition in antibody-antigen complexes
With the numerous detailed molecular descriptions of antibody-antigen interfaces, the
structural study of these molecular interactions has evolved from an attempt to understand …
structural study of these molecular interactions has evolved from an attempt to understand …
Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics
RMJ Liskamp, DTS Rijkers, JAW Kruijtzer… - …, 2011 - Wiley Online Library
Despite their enormous diversity in biological function and structure, peptides and proteins
are endowed with properties that have induced and stimulated the development of …
are endowed with properties that have induced and stimulated the development of …
Structural dissimilarity from self drives neoepitope escape from immune tolerance
JR Devlin, JA Alonso, CM Ayres, GLJ Keller… - Nature chemical …, 2020 - nature.com
T-cell recognition of peptides incorporating nonsynonymous mutations, or neoepitopes, is a
cornerstone of tumor immunity and forms the basis of new immunotherapy approaches …
cornerstone of tumor immunity and forms the basis of new immunotherapy approaches …
Current experimental methods for characterizing protein–protein interactions
M Zhou, Q Li, R Wang - ChemMedChem, 2016 - Wiley Online Library
Protein molecules often interact with other partner protein molecules in order to execute their
vital functions in living organisms. Characterization of protein–protein interactions thus plays …
vital functions in living organisms. Characterization of protein–protein interactions thus plays …
Flexibility and conformational entropy in protein-protein binding
To better understand the interplay between protein-protein binding and protein dynamics,
we analyzed molecular dynamics simulations of 17 protein-protein complexes and their …
we analyzed molecular dynamics simulations of 17 protein-protein complexes and their …