Neurodegeneration is the pathological condition, in which the nervous system or neuron
loses its structure, function, or both, leading to progressive degeneration or the death of …

The protein dyshomeostasis is identified as the hallmark of many age-related
neurodegenerative disorders including Parkinson's disease (PD). The diseased brain shows …

The pathogenesis and clinical heterogeneity of Parkinson's disease (PD) have been
evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …

Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent
two most common genetic causes of Parkinson's disease (PD). Both genes are important in …

Parkinson's disease (PD) is the second most common neurodegenerative illness majorly
affecting the population between the ages of 55 to 65 years. Progressive dopaminergic …

Parkinson's disease (PD) is the second most common neurodegenerative disease. The
development of PD is closely linked to genetic and environmental factors, with GBA1 …

Advances in genome sequencing have enabled researchers and clinicians to probe vast
numbers of human variants to distinguish pathogenic from benign variants. Model …

Progressive degeneration of neurons and aggravation of dopaminergic neurons in the
substantia nigra pars compacta results in the loss of dopamine in the brain of Parkinson's …

Mutations in the GBA1 gene are the single most frequent genetic risk factor for Parkinson's
disease (PD). Neurodegenerative changes in GBA1-associated PD have been linked to the …