Chemistry, pharmacology and therapeutic potential of swertiamarin–A promising natural lead for new drug discovery and development

NS Muhamad Fadzil, M Sekar, SH Gan… - Drug design …, 2021 - Taylor & Francis
Swertiamarin, a seco-iridoid glycoside, is mainly found in Enicostemma littorale Blume (E.
littorale) and exhibits therapeutic activities for various diseases. The present study aimed to …

Biologically active secoiridoids: A comprehensive update

Z Peng, J He, Y Cheng, J Xu… - Medicinal Research …, 2023 - Wiley Online Library
Secoiridoids are natural products of cyclopentane monoterpene derivatives that are formed
by splitting the rings of cyclomethene oxime compounds at C‐7 and C‐8, and only account …

Thymoquinone attenuates diabetes-induced hepatic damage in rat via regulation of oxidative/nitrosative stress, apoptosis, and inflammatory cascade with molecular …

MH Hafez, SM Ez Elarab, HG Tohamy, AH El-Far - Scientific Reports, 2024 - nature.com
Diabetes mellitus (DM) is a complex metabolic condition that causes organ dysfunction. The
current experiment sought to determine the effect of thymoquinone (TQ) on hyperglycemia …

Can Polyherbal Medicine be used for the Treatment of Diabetes?-A Review of Historical Classics, Research Evidence and Current Prevention Programs

S Brahma, AK Goyal, P Dhamodhar… - Current Diabetes …, 2024 - benthamdirect.com
Diabetes mellitus (DM), a chronic medical condition, has attained a global pandemic status
over the last few decades affecting millions of people. Despite a variety of synthetic drugs …

A systematic review of the protective role of swertiamarin in cardiac and metabolic diseases

XY Leong, PV Thanikachalam, M Pandey… - Biomedicine & …, 2016 - Elsevier
Background Swertiamarin, is a secoiridoid glycoside found in genera of Enicostemma
Species (Enicostemma littorale and Enicostemma axillare) belonging to the family of …

Centaurium erythraea extract improves survival and functionality of pancreatic beta-cells in diabetes through multiple routes of action

M Đorđević, N Grdović, M Mihailović… - Journal of …, 2019 - Elsevier
Abstract Ethnopharmacological relevance Centaurium erythraea Rafn (CE) is used as a
traditional medicinal plant in Serbia to treat different ailments due to its antidiabetic …

Mining of efficient microbial UDP-glycosyltransferases by motif evolution cross plant kingdom for application in biosynthesis of salidroside

B Fan, T Chen, S Zhang, B Wu, B He - Scientific reports, 2017 - nature.com
The plant kingdom provides a large resource of natural products and various related
enzymes are analyzed. The high catalytic activity and easy genetically modification of …

Use of monoterpenes as potential therapeutics in diabetes mellitus: A prospective review

LR Sousa, NR Viana, AG Coêlho… - Advances in …, 2023 - Wiley Online Library
Monoterpenes are secondary metabolites of plants belonging to the terpenoid class of
natural products. They are the most abundant components of essential oils that are …

[HTML][HTML] A review on the ethnomedicinal usage, phytochemistry, and pharmacological properties of Gentianeae (Gentianaceae) in Tibetan medicine

X Chi, F Zhang, Q Gao, R **ng, S Chen - Plants, 2021 - mdpi.com
Gentianaceae is a large plant family and is distributed worldwide. As the largest tribe in
Gentianaceae, Gentianeae contains 939–968 species, and the Qinghai-Tibet Plateau and …

[PDF][PDF] Investigation of the protective and therapeutic effects of β-aminoisobutyric acid (BAIBA) and Thymoquinone in the diabetic nephropathy

İ Aktaş, FM Gür - Boletin Latinoamericano Y Del Caribe de Plantas …, 2021 - academia.edu
In this study, against streptozotocin (STZ) induced diapetic nephropathy (DN); it is aimed to
investigate the use of thymoquinone (TQ) and β-aminoisobutyric acid (BAIBA) and to …