Over the last two and a half decades, photoacoustic (PA) imaging has become an important
area of research in biomedical optics. Combining the high contrast of optical imaging with …

Abstract Background and Aims No effective treatments are available for liver fibrosis.
Angiogenesis is deeply involved in liver fibrogenesis. However, current controversial results …

Mouse models of non-alcoholic fatty liver disease (NAFLD) are required to define
therapeutic targets, but detailed time-resolved studies to establish a sequence of events are …

The mycotoxin ochratoxin A (OTA) is a contaminant in food that causes nephrotoxicity and to
a minor degree hepatotoxicity. Recently, we observed that OTA induces liver damage …

Mouse models are frequently used to study chronic liver diseases (CLDs). To assess their
translational relevance, we quantified the similarity of commonly used mouse models to …

Mesenchymal stem cell (MSC) therapy has become a promising treatment for liver fibrosis
due to its predominant immunomodulatory performance in hepatic stellate cell inhibition and …

There is a lack of systematic research exploring cross-species variation in liver lobular
geometry and zonation patterns of critical drug-metabolizing enzymes, a knowledge gap …

To transfer toxicological findings from model systems, eg animals, to humans, standardized
safety factors are applied to account for intra-species and inter-species variabilities. An …

Liver cirrhosis is a frequent condition with high impact on patients' life expectancy and health
care systems. Cirrhotic portal hypertension (PH) gradually develops with deteriorating liver …

Hypoalbuminemia (HA) is frequently observed in systemic inflammatory diseases and in
liver disease. However, the influence of HA on the pharmacokinetics and toxicity of …