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Glial polarization in neurological diseases: Molecular mechanisms and therapeutic opportunities
Glial cell polarization plays a pivotal role in various neurological disorders. In response to
distinct stimuli, glial cells undergo polarization to either mitigate neurotoxicity or facilitate …
distinct stimuli, glial cells undergo polarization to either mitigate neurotoxicity or facilitate …
Effects of low-dose acetylsalicylic acid on the inflammatory response to experimental sleep restriction in healthy humans
Background Sleep deficiencies, such as manifested in short sleep duration or insomnia
symptoms, are known to increase the risk for multiple disease conditions involving …
symptoms, are known to increase the risk for multiple disease conditions involving …
Synthesis and anti‐inflammatory activity of novel firocoxib analogues with balanced COX inhibition
J Xu, K Tang, Z Ju - Chemical Biology & Drug Design, 2024 - Wiley Online Library
The adverse effects caused by nonselective and selective cyclooxygenase‐2 (COX‐2)
inhibitors remain a challenge for current anti‐inflammatory medications. A balanced …
inhibitors remain a challenge for current anti‐inflammatory medications. A balanced …
A further pocket or conformational plasticity by map** COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet …
R Solidoro, M Miciaccia, C Bonaccorso… - European Journal of …, 2024 - Elsevier
Cyclooxygenase enzymes have distinct roles in cardiovascular, neurological, and
neurodegenerative disease. They are differently expressed in different type of cancers …
neurodegenerative disease. They are differently expressed in different type of cancers …
Heterocycle-guided synthesis of m-hetarylanilines via three-component benzannulation
AR Galeev, MV Dmitriev, AS Novikov… - Beilstein Journal of …, 2024 - beilstein-journals.org
A one-pot three-component synthesis of substituted meta-hetarylanilines from heterocycle-
substituted 1, 3-diketones has been developed. The electron-withdrawing power of the …
substituted 1, 3-diketones has been developed. The electron-withdrawing power of the …