Background Informed consent is one of the cornerstones of biomedical research with human
subjects. Research ethics committees may allow for a modification or a waiver of consent …

Clinical research has expanded tremendously in the past few decades and consequently
there has been growing interest in the ethical guidelines that are being followed for the …

Background. Pneumonia is the leading cause of childhood death in the develo** world.
Higher-quality etiological data are required to reduce this mortality burden. Methods. We …

Purpose The life-saving role of oxygen therapy in African children with severe pneumonia is
not yet established. Methods The open-label fractional-factorial COAST trial randomised …

Objective To determine the feasibility of Fluids in Shock, a randomised controlled trial (RCT)
of restricted fluid bolus volume (10 mL/kg) versus recommended practice (20 mL/kg). Design …

Objective Alternatives to prospective informed consent to enable children with life-
threatening conditions to be entered into trials of emergency treatments are needed. Across …

Abstract Background The World Health Organization recommends not performing
transfusions in African children hospitalized for uncomplicated severe anemia (hemoglobin …

Background Sickle cell anaemia (SCA) has historically been associated with high levels of
childhood mortality in Africa. Although malaria has a major contribution to this mortality, to …

Background The British Paediatric Association, the forerunner of the Royal College of
Paediatrics and Child Health (RCPCH), first published guidance in relation to research …

Background Obtaining prospective written consent from women to participate in trials when
they are experiencing an obstetric emergency is challenging. Alternative consent pathways …