Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

BACKGROUND In adult mammalian organisms, multiple tissues—including the skin, blood,
stomach, and intestines—are entrapped in a state of permanent regeneration; older cells are …

Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal
epithelium has become a prime model for studying adult stem cells in health and disease …

Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis …

Wnt signaling is one of the key oncogenic pathways in multiple cancers, and targeting this
pathway is an attractive therapeutic approach. However, therapeutic success has been …

Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic
traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) …

Intestinal stem and progenitor cells replicate and differentiate in distinct compartments,
influenced by Wnt, BMP, and other subepithelial cues. The cellular sources of these signals …

Food-derived exosome-like nanoparticles pass through the intestinal tract throughout our
lives, but little is known about their impact or function. Here, as a proof of concept, we show …

The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and
frequently co-opted during tumor development. Almost all colorectal cancers (CRC) …