Collapsin response mediator proteins (CRMPs) are a family of ubiquitously expressed,
homologous phosphoproteins best known for coordinating cytoskeletal formation and …

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Persistent sodium current (INaP) is an important activity-dependent regulator of neuronal
excitability. It is involved in a variety of physiological and pathological processes, including …

Treatments for chronic pain are inadequate, and new options are needed.
Nonpharmaceutical approaches are especially attractive with many potential advantages …

This work aimed to develop and produce lacosamide-loaded niosomes coated with chitosan
(LCA-CTS-NSM) using a thin-film hydration method and the Box-Behnken design. The effect …

Abstract Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disease linked to
mutations of the Nf1 gene. Patients with NF1 commonly experience severe pain. Studies on …

We previously reported that destruction of the small ubiquitin-like modifier (SUMO)
modification site in the axonal collapsin response mediator protein 2 (CRMP2) was sufficient …

Collapsin response mediator proteins 1− 5 (CRMPs1− 5) are a family of cytosolic proteins
that coordinate neuronal migration, axonal guidance, dendritic organization, dendritic spine …

Abstract The Federal Pain Research Strategy recommended development of nonopioid
analgesics as a top priority in its strategic plan to address the significant public health crisis …

Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many
neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are …