Cre recombinase is a phage-derived enzyme that has found utility for precise manipulation
of DNA sequences. Cre recognizes and recombines pairs of loxP sequences characterized …

Understanding the mechanisms of protein-DNA binding is critical in comprehending gene
regulation. Three-dimensional DNA structure, also described as DNA shape, plays a key …

Abstract Structure and deformability of the DNA double helix play a key role in protein and
small ligand binding, in genome regulation via loo**, or in nanotechnology applications …

The subtle differences in the chemical structures of double-stranded (ds) RNA and DNA lead
to significant variations in their biological roles and medical implications, largely due to their …

In eukaryotes, structural maintenance of chromosomes (SMC) complexes form topologically
associating domains (TADs) by extruding DNA loops and being stalled by roadblock …

Despite the negative charge of the DNA backbone, acidic residues (Asp/Glu) commonly
participate in the base readout, with a strong preference for cytosine. In fact, in the solved …

Bacterial adaptation is largely shaped by horizontal gene transfer, xenogeneic silencing
mediated by lineage-specific DNA bridgers (H-NS, Lsr2, MvaT and Rok), and various anti …

Mechanically bonded membranes of interlocked ring polymers are a significant
generalization of conventional elastic sheets, where connectivity is provided by covalent …

Despite its rigid structure, DNA is a remarkably flexible molecule. Flexibility is essential for
biological functions (such as transcription and gene repair), which require large-amplitude …

DNA carries the genetic information required for the synthesis of RNA and proteins and
plays an important role in many processes of biological development. Understanding the …