Background: Dementia is a devastating neurologic condition that is common in older adults.
We previously reviewed the epidemiological evidence examining the hypothesis that long …

The explosion and abundance of digital data could facilitate large-scale research for
psychiatry and mental health. Research using so-called “real world data”—such as …

Background and Objectives Repurposing phosphodiesterase type 5 inhibitors (PDE5Is) as
drugs for Alzheimer disease (AD) risk reduction has shown promise based on animal …

Background and Objectives Whether chronic autoimmune inflammatory diseases causally
affect the risk of Alzheimer disease (AD) is controversial. We characterized the relationship …

The accumulation and systemic propagation of senescent cells contributes to physiological
aging and age-related pathology. However, which cell types are most susceptible to the …

Introduction We aimed to investigate ethnic differences in the associations of potentially
modifiable risk factors with dementia. Methods We used anonymised data from English …

The root causes of dementia are still largely unclear, and the medical community lacks
highly effective preventive and therapeutic pharmaceutical agents for dementia despite …

Background and Objectives Little is known about the benefits of statin therapy in older adults
with dementia. We aimed to evaluate the role of statin use for all-cause mortality in nursing …

Objective The aim of this study was to investigate the association between oral
anticoagulant type (direct oral anticoagulants (DOACs) vs vitamin K antagonists (VKAs)) and …

Background Electronic health records are widely used in cardiovascular disease research.
We appraised the validity of stroke, acute coronary syndrome and heart failure diagnoses in …