Streptococcus pneumoniae's Virulence and Host Immunity: Aging, Diagnostics, and Prevention

LRK Brooks, GI Mias - Frontiers in immunology, 2018 - frontiersin.org
Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

Mechanisms and regulation of extracellular DNA release and its biological roles in microbial communities

AL Ibáñez de Aldecoa, O Zafra… - Frontiers in …, 2017 - frontiersin.org
The capacity to release genetic material into the extracellular medium has been reported in
cultures of numerous species of bacteria, archaea, and fungi, and also in the context of …

Dense genomic sampling identifies highways of pneumococcal recombination

C Chewapreecha, SR Harris, NJ Croucher, C Turner… - Nature …, 2014 - nature.com
Evasion of clinical interventions by Streptococcus pneumoniae occurs through selection of
non-susceptible genomic variants. We report whole-genome sequencing of 3,085 …

Kee** the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems

WT Chan, M Espinosa, CC Yeo - Frontiers in molecular biosciences, 2016 - frontiersin.org
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to
bacterial plasmids where they function to mediate the maintenance and stability of usually …

Competence in Streptococcus pneumoniae and Close Commensal Relatives: Mechanisms and Implications

G Salvadori, R Junges, DA Morrison… - Frontiers in cellular and …, 2019 - frontiersin.org
The mitis group of streptococci comprises species that are common colonizers of the naso-
oral-pharyngeal tract of humans. Streptococcus pneumoniae and Streptococcus mitis are …

Influence of bacterial interactions on pneumococcal colonization of the nasopharynx

JR Shak, JE Vidal, KP Klugman - Trends in microbiology, 2013 - cell.com
Streptococcus pneumoniae (the pneumococcus) is a common commensal inhabitant of the
nasopharynx and a frequent etiologic agent in serious diseases such as pneumonia, otitis …

A visual review of the human pathogen Streptococcus pneumoniae

DH Engholm, M Kilian, DS Goodsell… - FEMS microbiology …, 2017 - academic.oup.com
Being the principal causative agent of bacterial pneumonia, otitis media, meningitis and
septicemia, the bacterium Streptococcus pneumoniae is a major global health problem. To …

LytA, major autolysin of Streptococcus pneumoniae, requires access to nascent peptidoglycan

P Mellroth, R Daniels, A Eberhardt, D Rönnlund… - Journal of Biological …, 2012 - ASBMB
The pneumococcal autolysin LytA is a virulence factor involved in autolysis as well as in
fratricidal-and penicillin-induced lysis. In this study, we used biochemical and molecular …

Streptococcus pneumoniae epidemiology, pathogenesis and control

AR Narciso, R Dookie, P Nannapaneni… - Nature Reviews …, 2024 - nature.com
Infections caused by Streptococcus pneumoniae (also known as pneumococci) pose a
threat to human health. Pneumococcal infections are the most common cause of milder …

The impact of horizontal gene transfer on the adaptive ability of the human oral microbiome

AP Roberts, J Kreth - Frontiers in cellular and infection microbiology, 2014 - frontiersin.org
The oral microbiome is composed of a multitude of different species of bacteria, each
capable of occupying one or more of the many different niches found within the human oral …