If we have any hope of achieving a cure for HIV infection, close attention to the cell types
capable of getting infected with HIV is necessary. Of these cell types, astrocytes are the most …

Helicases are ubiquitous motor proteins that separate and/or rearrange nucleic acid
duplexes in reactions fueled by adenosine triphosphate (ATP) hydrolysis. Helicases …

To identify key regulators of human brain tumor maintenance and initiation, we performed
multiple genome-wide RNAi screens in patient-derived glioblastoma multiforme (GBM) stem …

The viral genome-linked protein, VPg, of potyviruses is a multifunctional protein involved in
viral genome translation and replication. Previous studies have shown that both eukaryotic …

Active host-pathogen interactions take place during infection of human immunodeficiency
virus type 1 (HIV-1). Outcomes of these interactions determine the efficiency of viral infection …

RNA helicases unwind their RNA substrates in an ATP-dependent reaction, and are central
to all cellular processes involving RNA. They have important roles in viral life cycles, where …

The human immunodeficiency virus (HIV-1) differentially controls viral protein expression at
the level of splicing as well as nuclear export of incompletely spliced viral RNA. This …

RNA helicases serve multiple roles at the virus-host interface. In some situations, RNA
helicases are essential host factors to promote viral replication; however, in other cases they …

The emergence of drug-resistant HIV-1 strains presents a challenge for the design of new
therapy. Targeting host cell factors that regulate HIV-1 replication might be one way to …

Japanese encephalitis virus is one of the most common causes for epidemic viral
encephalitis in humans and animals. Herein we demonstrated that cellular helicase DDX3 is …