Scale matters: the nested human connectome

M Axer, K Amunts - Science, 2022 - science.org
A comprehensive description of how neurons and entire brain regions are interconnected is
fundamental for a mechanistic understanding of brain function and dysfunction …

[HTML][HTML] Post mortem map** of connectional anatomy for the validation of diffusion MRI

A Yendiki, M Aggarwal, M Axer, AFD Howard… - NeuroImage, 2022 - Elsevier
Diffusion MRI (dMRI) is a unique tool for the study of brain circuitry, as it allows us to image
both the macroscopic trajectories and the microstructural properties of axon bundles in vivo …

Parcellating cerebral cortex: how invasive animal studies inform noninvasive mapmaking in humans

DC Van Essen, MF Glasser - Neuron, 2018 - cell.com
The cerebral cortex in mammals contains a mosaic of cortical areas that differ in function,
architecture, connectivity, and/or topographic organization. A combination of local …

Multiscale label-free imaging of myelin in human brain tissue with polarization-sensitive optical coherence tomography and birefringence microscopy

N Blanke, S Chang, A Novoseltseva… - Biomedical Optics …, 2023 - opg.optica.org
The combination of polarization-sensitive optical coherence tomography (PS-OCT) and
birefringence microscopy (BRM) enables multiscale assessment of myelinated axons in …

Revealing architectural order with quantitative label-free imaging and deep learning

SM Guo, LH Yeh, J Folkesson, IE Ivanov, AP Krishnan… - elife, 2020 - elifesciences.org
We report quantitative label-free imaging with phase and polarization (QLIPP) for
simultaneous measurement of density, anisotropy, and orientation of structures in unlabeled …

Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography

S Cheng, S Chang, Y Li, A Novoseltseva… - Light: Science & …, 2025 - nature.com
A major challenge in neuroscience is visualizing the structure of the human brain at different
scales. Traditional histology reveals micro-and meso-scale brain features but suffers from …

[HTML][HTML] Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain

R Jones, G Grisot, J Augustinack, C Magnain, DA Boas… - Neuroimage, 2020 - Elsevier
In the first study comparing high angular resolution diffusion MRI (dMRI) in the human brain
to axonal orientation measurements from polarization-sensitive optical coherence …

Topographic Axes of Wiring Space Converge to Genetic Topography in Sha** Human Cortical Layout

D Li, Y Wang, L Ma, Y Wang, L Cheng, Y Liu… - Journal of …, 2025 - jneurosci.org
Genetic information is involved in the gradual emergence of cortical areas since the neural
tube begins to form, sha** the heterogeneous functions of neural circuits in the human …

Refractive-index matching enhanced polarization sensitive optical coherence tomography quantification in human brain tissue

CJ Liu, W Ammon, RJ Jones, J Nolan… - Biomedical Optics …, 2021 - opg.optica.org
The importance of polarization-sensitive optical coherence tomography (PS-OCT) has been
increasingly recognized in human brain imaging. Despite the recent progress of PS-OCT in …

Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system

H Takemura, N Palomero-Gallagher, M Axer, D Gräßel… - Elife, 2020 - elifesciences.org
Although the primate visual system has been extensively studied, detailed spatial
organization of white matter fiber tracts carrying visual information between areas has not …