The consequences of matrix effects in mass spectrometry analysis are a major issue of
concern to analytical chemists. The identification of any ion suppressing (or enhancing) …

After discussing the significance of preliminary operations, such as selection or storage of
biological samples, we critically review the other steps of the analytical process prior to …

Exploratory or untargeted ultra performance liquid chromatography–mass spectrometry
(UPLC–MS) profiling offers an overview of the complex lipid species diversity present in …

The aim of metabolite profiling is to monitor all metabolites within a biological sample for
applications in basic biochemical research as well as pharmacokinetic studies and …

In this tutorial, the mechanism and origin of ion suppression will be investigated, as well as
ways to validate the presence, and circumvent or compensate for, the effects in LC-MS.Ion …

Bioorthogonal drug molecules are currently gaining prominence for their excellent efficacy,
safety and metabolic stability. Pharmacokinetic study is critical for understanding their …

Abstract Since coronavirus disease 2019 (COVID-19) started as a fast-spreading pandemic,
causing a huge number of deaths worldwide, several therapeutic options have been tested …

The importance of sample preparation methods as the first stage in bioanalysis is described.
In this article, the sample preparation concept and strategies will be discussed, along with …

Paxlovid, a copackaged medication of nirmatrelvir tablets (150 mg) and ritonavir tablets (100
mg) developed by Pfizer, is one of the first orally accessible COVID‐19 antiviral medicines to …

An assessment of cytochrome P450 (CYP) enzyme activity is essential for characterizing the
phase I metabolism of biological systems or to evaluate the inhibition/induction properties of …