The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Accumulation of tau has been implicated in various neurodegenerative diseases termed
tauopathies. Tau is a microtubule-associated protein but is also actively released into the …

The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …

Importance An association between sleep duration and the trajectory of cognitive decline
has not been conclusively demonstrated. Objective To investigate the association between …

The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in
recent years, highlighted that fluid is directionally transported within the central nervous …

Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …