Throughout life, T cells coordinate multiple aspects of adaptive immunity, including
responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is …

Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Cytotoxic CD8 T lymphocytes play a central role in the tissue destruction of many
autoimmune disorders. In type 1 diabetes (T1D), insulin and its precursor preproinsulin are …

It is increasingly appreciated that the pathogenic mechanisms of type 1 diabetes involve
both the autoimmune aggressors and their beta cell targets, which engage in a conflicting …

Efficient immune responses against invading pathogens often involve coordination between
cells from both the innate and adaptive immune systems. For multiple decades, it has been …

In chronic inflammatory diseases of the central nervous system (CNS), immune cells
persisting behind the blood-brain barrier are supposed to promulgate local tissue …

The pathogenesis of autoimmunity remains to be fully elucidated, although the contribution
of genetic and environmental factors is generally recognized. Despite autoimmune …

Non-recirculating tissue-resident memory T cells (TRMs) are the predominant T cell subset
in diverse tissue sites, where they mediate protective immune responses in situ. Here, we …

Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the
leading cause of end‐stage kidney disease. Inflammation is recognized as an important …