Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Amorphous solid dispersions are an increasingly important formulation approach to improve
the dissolution rate and apparent solubility of poorly water soluble compounds. Due to their …

The purpose of this study is to investigate the mechanism of protein stabilization by sugars in
the solid state. That is, explore whether the stabilization is controlled by “glass dynamics” or …

The solid state is preferred for many proteins due to their marginal stability in solution.
However, even in the solid state, chemical and physical degradation can occur on the time …

The biopharmaceutical properties—especially the solubility and permeability—of a molecule
contribute to its overall therapeutic efficacy. The newer tools of drug discovery have caused …

Amorphous solids are conventionally formed by supercooling liquids or by concentrating
noncrystallizing solutes (spray-drying and freeze-drying). However, a lot of pharmaceutical …

Vitrification is a process in which a liquid begins to behave as a solid during cooling without
any substantial change in molecular arrangement or thermodynamic state variables. The …

Recent studies have demonstrated that molecular mobility is an important factor affecting the
chemical stability of amorphous pharmaceuticals, including small-molecular-weight drugs …

Glass-former fragility describes the changing dynamics of a supercooled liquid with
temperature and so dictates the temperature of glass transition as well as the dynamics of …

Purpose. To determine the effect of moisture and the role of the glass transition temperature
(T g) on the stability of a high concentration, lyophilized, monoclonal antibody. Methods. A …