The immune system responds to cancer in two main ways. First, there are prewired
responses involving myeloid cells, innate lymphocytes and innate-like adaptive lymphocytes …

Tumors are populated by antigen-presenting cells (APCs) including macrophage subsets
with distinct origins and functions. Here, we examined how cancer impacts mononuclear …

In metazoan organisms, cell competition acts as a quality control mechanism to eliminate
unfit cells in favour of their more robust neighbours,. This mechanism has the potential to be …

Immunotherapy has become a key new pillar of cancer treatment, and this has sparked
interest in understanding mechanisms of cancer immune evasion. It has long been …

To date, no immunotherapy approaches have managed to fully overcome T-cell exhaustion,
which remains a mandatory fate for chronically activated effector cells and a major …

Fructose consumption is associated with tumor growth and metastasis in mice, yet its impact
on antitumor immune responses remains unclear. Here, we show that dietary fructose …

Cancer cells edit gene expression to evade immunosurveillance. However, genome-wide
studies of gene editing during early tumorigenesis are lacking. Here we used single-cell …

The success of tumor immunotherapy highlights the potential of harnessing immune system
to fight cancer. Activating both native T cells and exhausted T cells is a critical step for …

Naked mole-rats (NMRs) are best known for their extreme longevity and cancer resistance,
suggesting that their immune system might have evolved to facilitate these phenotypes …

The intestinal immune system must tolerate food antigens to avoid allergy, a process
requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we …