Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …

Research on all stages of fibrin polymerization, using a variety of approaches including
naturally occurring and recombinant variants of fibrinogen, x-ray crystallography, electron …

Hemostasis requires the tightly regulated interaction of the coagulation system, platelets,
other blood cells and components of the vessel wall at a site of vascular injury. The …

Achieving hemostasis following vascular injury requires the rapid accumulation of platelets
and fibrin. Here we used a combination of confocal intravital imaging, genetically …

Platelets interact with the coagulation system in a multitude of ways, not only during the
phases of thrombus formation, but also in specific areas within a formed thrombus. This …

Intravascular blood clots form in an environment in which hydrodynamic forces dominate
and in which fluid-mediated transport is the primary means of moving material. The clotting …

Hemostatic thrombi develop a characteristic architecture in which a core of highly activated
platelets is covered by a shell of less-activated platelets. Here we have used a systems …

The study of blood ex vivo can occur in closed or open systems, with or without flow.
Microfluidic devices, which constrain fluids to a small (typically submillimeter) scale, facilitate …

The short‐and long‐term thrombogenicity of implant materials is still unpredictable, which is
a significant challenge for the treatment of cardiovascular diseases. A knowledge‐based …

The systems analysis of thrombosis seeks to quantitatively predict blood function in a given
vascular wall and hemodynamic context. Relevant to both venous and arterial thrombosis, a …