The pathophysiology of sepsis and precision-medicine-based immunotherapy

EJ Giamarellos-Bourboulis, AC Aschenbrenner… - Nature …, 2024 - nature.com
Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

Perforated and bleeding peptic ulcer: WSES guidelines

A Tarasconi, F Coccolini, WL Biffl, M Tomasoni… - World journal of …, 2020 - Springer
Background Peptic ulcer disease is common with a lifetime prevalence in the general
population of 5–10% and an incidence of 0.1–0.3% per year. Despite a sharp reduction in …

SIRS, qSOFA and new sepsis definition

PE Marik, AM Taeb - Journal of thoracic disease, 2017 - pmc.ncbi.nlm.nih.gov
© Journal of Thoracic Disease. All rights reserved. J Thorac Dis 2017; 9 (4): 943-945 jtd.
amegroups. com of data collection for clinical trials in the intensive care unit (ICU). However …

Prognostic accuracy of the quick sequential organ failure assessment for mortality in patients with suspected infection: a systematic review and meta-analysis

SM Fernando, A Tran, M Taljaard, W Cheng… - Annals of internal …, 2018 - acpjournals.org
Background: The quick Sequential Organ Failure Assessment (qSOFA) has been proposed
for prediction of mortality in patients with suspected infection. Purpose: To summarize and …

Toward personalized immunotherapy in sepsis: The PROVIDE randomized clinical trial

K Leventogiannis, E Kyriazopoulou, N Antonakos… - Cell Reports …, 2022 - cell.com
The state of immune activation may guide targeted immunotherapy in sepsis. In a double-
blind, double-dummy randomized clinical study, 240 patients with sepsis due to lung …

Performance of the quick Sequential (sepsis-related) Organ Failure Assessment score as a prognostic tool in infected patients outside the intensive care unit: a …

JU Song, CK Sin, HK Park, SR Shim, J Lee - Critical Care, 2018 - Springer
Background The usefulness of the quick Sequential (Sepsis-related) Organ Failure
Assessment (qSOFA) score in providing bedside criteria for early prediction of poor …

Sepsis and septic shock: New definitions, new diagnostic and therapeutic approaches

S Esposito, G De Simone, G Boccia, F De Caro… - Journal of global …, 2017 - Elsevier
Sepsis and septic shock are common life-threatening pathologies associated with high
mortality and substantial costs for healthcare system. Clinical guidelines and bundles for the …

Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis

E Kyriazopoulou, K Leventogiannis, A Norrby-Teglund… - BMC medicine, 2017 - Springer
Background A subanalysis of a randomized clinical trial indicated sepsis survival benefit
from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like …

[HTML][HTML] Accuracy of quick Sequential Organ Failure Assessment (qSOFA) score and systemic inflammatory response syndrome (SIRS) criteria for predicting mortality …

S Maitra, A Som, S Bhattacharjee - Clinical Microbiology and Infection, 2018 - Elsevier
Objective To identify sensitivity, specificity and predictive accuracy of quick sequential organ
failure assessment (qSOFA) score and systemic inflammatory response syndrome (SIRS) …

[HTML][HTML] NEWS2 is superior to qSOFA in detecting sepsis with organ dysfunction in the emergency department

L Mellhammar, A Linder, J Tverring… - Journal of clinical …, 2019 - mdpi.com
Early administration of antibiotics is associated with better survival in sepsis, thus screening
and early detection for sepsis is of clinical importance. Current risk stratification scores used …