Nucleic acids are the foundation of life. Specific sequences translate certain genetic traits,
protein expression, and, ultimately, cellular function. Yet, nucleic acids not only store genetic …

Systematic evolution of ligand by exponential enrichment (SELEX) is an efficient method
used to isolate high-affinity single stranded oligonucleotides from a large random sequence …

Aptamers are single-stranded oligonucleotides of DNA or RNA that bind to target molecules
with high affinity and specificity. Typically, aptamers are generated by an iterative selection …

Parkinson's disease (PD) is characterized by intraneuronal inclusions of aggregated α-
synuclein protein (so-called Lewy bodies) in distinct brain regions. Multiple posttranslational …

With the development of antibiotic-resistant bacterial strains, infectious diseases have
become again a life-threatening problem. One of the reasons for this dilemma is the limited …

The emergence of shotgun proteomics has facilitated the numerous biological discoveries
made by proteomic studies. However, comprehensive proteomic analysis remains …

Precisely knowing the stoichiometry of their components is critical for investigating structure,
assembly, and function of macromolecular machines. This has remained a technical …

Showdomycin is a potent nucleoside antibiotic that displays a high structural similarity to
uridine and pseudouridine. No detailed target analysis of this very unusual electrophilic …

The importance of membrane proteins in biological systems is indisputable; however, their
amphipathic nature makes them difficult to analyze. In this study, the most popular …

Mass spectrometry (MS) based proteomic technologies enable the identification and
quantification of membrane proteins as well as their post-translational modifications. A …