This review presents the roles of cardiac sodium channel NaV1. 5 late current (late I Na) in
generation of arrhythmic activity. The assumption of the authors is that proper Na+ channel …

The “late sodium current”(INaL) is a sustained component of the fast Na+ current of cardiac
myocytes and neurons. As recently appreciated, common neurological and cardiac …

Andersen syndrome (AS) is a rare, inherited disorder characterized by periodic paralysis,
long QT (LQT) with ventricular arrhythmias, and skeletal developmental abnormalities. We …

Sodium overload of cardiac cells can accompany various pathologies and induce fatal
cardiac arrhythmias. We investigate effects of elevated intracellular sodium on the cardiac …

An important acknowledgement of the last several years is that atrial fibrillation (AF) modifies
the electrical properties of the atrium in a way that promotes its occurrence and …

As a multisystem disorder, Andersen–Tawil syndrome (ATS) is rather unique in the family of
channelopathies. The full spectrum of the disease is characterized by ventricular …

In developmentally regulated D1: S3 splicing of Nav1. 5, there are 31 nucleotide differences
between the 5′‐exon ('neonatal') and the 3′‐exon ('adult') forms, resulting in 7 amino acid …

Abnormalities in repolarization and its rate dependence are known to be related to
increased proarrhythmic risk. A number of repolarization-related electrophysiological …

Background—The pathophysiology underlying electrophysiological remodeling (ER) from
rapid atrial rates is unknown. We tested the hypothesis that activation of the Na+/H+ …

In this study, several modifications were introduced to a recently proposed human
ventricular action potential (AP) model so as to render it suitable for the study of ventricular …