Overfeeding of rodents leads to increased local formation of angiotensin II due to increased
secretion of angiotensinogen from adipocytes. Whereas angiotensin II promotes adipocyte …

Obese individuals frequently develop hypertension, which is for an important part
attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review …

In obesity-related hypertension, activation of the renin-angiotensin system (RAS) has been
reported despite marked fluid volume expansion. Adipose tissue expresses components of …

Recent studies have demonstrated that the rat adipose tissue expresses some of the
components necessary for the production of angiotensin II (Ang II) and the receptors …

Previous studies demonstrated that overexpression of angiotensinogen (AGT) in adipose
tissue increased blood pressure. However, the contribution of endogenous AGT in …

Aims HIIT (high-intensity interval training) has the potential to reduce cardiometabolic risk
factors, but the effects on cardiac remodeling and local RAS (renin-angiotensin system) in …

The renin-angiotensin system (RAS) is a major determinant of blood pressure and
intravascular volume. Studies of this system have led to the development of important new …

Angiotensin II (Ang II) is a critical regulator of insulin signaling in the cardiovascular system
and metabolic tissues. However, in adipose cells, the regulatory role of Ang II on insulin …

Adipocytes secrete a variety of factors, including angiotensinogen, the only known precursor
to Angiotensin II (AngII). Recent studies suggest that adipocyte-derived angiotensinogen …

BACKGROUND AND PURPOSE Treatment with thiazolidinediones, insulin‐sensitizing
drugs, enhances adipogenesis, which may result in unwanted increase in adiposity. Based …