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Advances for pharmacological activities of Polygonum cuspidatum - A review
J Ke, MT Li, S Xu, J Ma, MY Liu, Y Han - Pharmaceutical Biology, 2023 - Taylor & Francis
Abstract Context Polygonum cuspidatum Sieb. et Zucc (Polygonaceae), the root of which is
included in the Chinese Pharmcopoeia under the name 'Huzhang', has a long history as a …
included in the Chinese Pharmcopoeia under the name 'Huzhang', has a long history as a …
[HTML][HTML] Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?
P Tang, T Shen, H Wang, R Zhang, X Zhang… - Biomedicine & …, 2023 - Elsevier
Bioactive natural products (BNPs) are the marrow of medicinal plants, which are the
secondary metabolites of organisms and have been the most famous drug discovery …
secondary metabolites of organisms and have been the most famous drug discovery …
Electrochemical Lactonization Enabled by Unusual Shono-Type Oxidation from Functionalized Benzoic Acids
C Liu, Y Liu, S Yang, B Zheng, Y Zhang - Organic Letters, 2024 - ACS Publications
A novel method for electrochemical lactonization via C (sp 3)–H functionalization was
developed. This metal-and oxidant-free strategy enabled the efficient synthesis of various …
developed. This metal-and oxidant-free strategy enabled the efficient synthesis of various …
Advanced metabolic engineering strategies for increasing artemisinin yield in Artemisia annua L.
Artemisinin, also known as 'Qinghaosu', is a chemically sesquiterpene lactone containing an
endoperoxide bridge. Due to the high activity to kill Plasmodium parasites, artemisinin and …
endoperoxide bridge. Due to the high activity to kill Plasmodium parasites, artemisinin and …
Facilitated drug repurposing with artemisinin-derived PROTACs: unveiling PCLAF as a therapeutic target
Y Li, ZW Zeng, D Chen, ZC Gu, WL Yan… - Journal of Medicinal …, 2023 - ACS Publications
Artemisinin, a prominent anti-malaria drug, is being investigated for its potential as a
repurposed cancer treatment. However, its effectiveness in tumor cell lines remains limited …
repurposed cancer treatment. However, its effectiveness in tumor cell lines remains limited …
Artemisinin-derived artemisitene blocks ROS-mediated NLRP3 inflammasome and alleviates ulcerative colitis
L Hua, S Liang, Y Zhou, X Wu, H Cai, Z Liu, Y Ou… - International …, 2022 - Elsevier
Artemisinins are well-known antimalarial drugs with clinical safety. In addition to antimalarial
effects, their anti-inflammatory and immunoregulatory properties have recently attracted …
effects, their anti-inflammatory and immunoregulatory properties have recently attracted …
Discovery and repurposing of artemisinin
Q Shi, F **a, Q Wang, F Liao, Q Guo, C Xu, J Wang - Frontiers of medicine, 2022 - Springer
Malaria is an ancient infectious disease that threatens millions of lives globally even today.
The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in …
The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in …
Currently available strategies for target identification of bioactive natural products
G Li, X Peng, Y Guo, S Gong, S Cao, F Qiu - Frontiers in Chemistry, 2021 - frontiersin.org
In recent years, biologically active natural products have gradually become important agents
in the field of drug research and development because of their wide availability and variety …
in the field of drug research and development because of their wide availability and variety …
New drug discovery and development from natural products: Advances and strategies
Y Wang, F Wang, W Liu, Y Geng, Y Shi, Y Tian… - Pharmacology & …, 2024 - Elsevier
Natural products (NPs) have a long history as sources for drug discovery, more than half of
approved drugs are related to NPs, which also exhibit multifaceted advantages in the clinical …
approved drugs are related to NPs, which also exhibit multifaceted advantages in the clinical …
Potential implications of hyperoside on oxidative stress-induced human diseases: A comprehensive review
K Wang, H Zhang, L Yuan, X Li… - Journal of Inflammation …, 2023 - Taylor & Francis
Hyperoside is a flavonol glycoside mainly found in plants of the genera Hypericum and
Crataegus, and also detected in many plant species such as Abelmoschus manihot, Ribes …
Crataegus, and also detected in many plant species such as Abelmoschus manihot, Ribes …