Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between
demyelination and remyelination can trigger progressive degenerative processes. The …

An imbalance between remyelinating and demyelinating rates underlies degenerative
processes in demyelinating diseases such as multiple sclerosis. An optimal therapeutic …

Demyelination is a hallmark of multiple sclerosis, leukoencephalopathies, cerebral
vasculopathies, and several neurodegenerative diseases. The cuprizone mouse model is …

The cuprizone mouse model allows the investigation of the complex molecular mechanisms
behind nonautoimmune-mediated demyelination and spontaneous remyelination. While it is …

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) which involves a complex interaction between immune system and neural …

In recent years, several studies have examined the potential associations between
mitochondrial dysfunction and neurodegenerative diseases such as multiple sclerosis (MS) …

Although astrogliosis and microglia activation are characteristic features of multiple sclerosis
(MS) and other central nervous system (CNS) lesions the exact functions of these events are …

Introduction: Demyelinating diseases of the central nervous system (CNS) comprise a group
of neurological disorders characterized by progressive (and eventually irreversible) loss of …

Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory, demyelinating, and
neurodegenerative disease of the central nervous system (CNS). Immune cell infiltration can …