In the frames of this review article the recently obtained data on new synthetic approaches to
fluorinated indoles, as well as their biological properties are considered.

Parkinson's Disease (PD) is a long-term neurodegenerative brain disorder that mainly
affects the motor system. The causes are still unknown, and even though currently there is …

During the last decade, the one drug-one target strategy has resulted to be inefficient in
facing diseases with complex ethiology like Alzheimer's disease and many others. In this …

With the purpose of expanding the structural variety of chemical compounds available as
pharmacological tools for the treatment of Alzheimer's disease, we synthesized and …

A series of 27 compounds of general structure 2, 3-dihydro-benzo [1, 4] oxazin-4-yl)-2-{4-[3-
(1 H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7 (a–o) and (2-{4-[3-(1 H-3 …

An overview of docking models of chain arylpiperazines to different subtypes of serotonin
receptors belonging to the GPCR family is presented. The theory of a ligand-receptor …

Evidence from systems biology indicates that promiscuous drugs, ie those that act
simultaneously at various protein targets, are clinically better in terms of efficacy, than those …

A series of novel 3‐indolylpropyl derivatives was synthesized and evaluated for their binding
affinities at the serotonin‐1A receptor subtype (5‐HT1AR) and the 5‐HT transporter (SERT) …

Abstract A series of 3-(3-(4-(3-(1H-indol-3-yl) propyl) piperazin-1-yl) propyl)-1H-indole
derivatives (3a–d and 5a–f) as homo-and hetero-bis-ligands, were synthesized and …

Alzheimer's Disease (AD) is one of the most common and complex age-related
neurodegenerative disorders in elderly people. Currently there is no cure for AD, and …