Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
RA Nixon, DC Rubinsztein - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …
through macromolecular breakdown to coordinate programmes for growth, repair and stress …
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I
K Yamamoto, A Venida, J Yano, DE Biancur… - Nature, 2020 - nature.com
Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion
include impaired antigen presentation caused by mutations or loss of heterozygosity of the …
include impaired antigen presentation caused by mutations or loss of heterozygosity of the …
mTOR at the nexus of nutrition, growth, ageing and disease
GY Liu, DM Sabatini - Nature reviews Molecular cell biology, 2020 - nature.com
The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …
Lysosome biogenesis: Regulation and functions
C Yang, X Wang - Journal of Cell Biology, 2021 - rupress.org
Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …
cellular homeostasis, development, and aging. Changes in lysosome function are essential …
Lysosome biology in autophagy
WWY Yim, N Mizushima - Cell discovery, 2020 - nature.com
Autophagy is a major intracellular degradation system that derives its degradative abilities
from the lysosome. The most well-studied form of autophagy is macroautophagy, which …
from the lysosome. The most well-studied form of autophagy is macroautophagy, which …
AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control
The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr682-phosphorylated APP βCTF
Lysosome dysfunction arises early and propels Alzheimer's disease (AD). Herein, we show
that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts …
that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts …
Mechanisms and functions of long non-coding RNAs at multiple regulatory levels
X Zhang, W Wang, W Zhu, J Dong, Y Cheng… - International journal of …, 2019 - mdpi.com
Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily
interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression …
interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression …