Protein cages: from fundamentals to advanced applications

TGW Edwardson, MD Levasseur, S Tetter… - Chemical …, 2022 - ACS Publications
Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

[HTML][HTML] Structure and function of legumain in health and disease

E Dall, H Brandstetter - Biochimie, 2016 - Elsevier
The last years have seen a steady increase in our understanding of legumain biology that is
driven from two largely uncoupled research arenas, the mammalian and the plant legumain …

Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor

M O'Connell Motherway, A Zomer… - Proceedings of the …, 2011 - National Acad Sciences
Development of the human gut microbiota commences at birth, with bifidobacteria being
among the first colonizers of the sterile newborn gastrointestinal tract. To date, the genetic …

Sortase enzymes in Gram‐positive bacteria

T Spirig, EM Weiner, RT Clubb - Molecular microbiology, 2011 - Wiley Online Library
In Gram‐positive bacteria proteins are displayed on the cell surface using sortase enzymes.
These cysteine transpeptidases join proteins bearing an appropriate sorting signal to …

Evaluation of the Function of Probiotics, Emphasizing the Role of their Binding to the Intestinal Epithelium in the Stability and their Effects on the Immune System

N Javanshir, GNG Hosseini, M Sadeghi… - Biological procedures …, 2021 - Springer
Due to the importance of using cost-effective methods for therapeutic purposes, the function
of probiotics as safe microorganisms and the study of their relevant functional mechanisms …

Drug and vaccine development for the treatment and prevention of urinary tract infections

VP O'brien, TJ Hannan, HV Nielsen… - Urinary Tract Infections …, 2017 - Wiley Online Library
Urinary tract infections (UTI) are one of the most common bacterial infections, with roughly
eleven‐million cases reported in the US each year that cost an estimated $5 billion annually …

Development of new spiro [1, 3] dithiine-4, 11′-indeno [1, 2-b] quinoxaline derivatives as S. aureus Sortase A inhibitors and radiosterilization with molecular …

A Ragab, MS Abusaif, NA Gohar, DS Aboul-Magd… - Bioorganic …, 2023 - Elsevier
Multi-drug resistant microbes have become a severe threat to human health and arise a
worldwide concern. A total of fifteen spiro-1, 3-dithiinoindenoquinoxaline derivatives 2–7 …

Architects at the bacterial surface—sortases and the assembly of pili with isopeptide bonds

APA Hendrickx, JM Budzik, SY Oh… - Nature Reviews …, 2011 - nature.com
The cell wall envelope of Gram-positive bacteria can be thought of as a surface organelle for
the assembly of macromolecular structures that enable the unique lifestyle of each …

Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria

WF Van Zyl, SM Deane, LMT Dicks - Gut microbes, 2020 - Taylor & Francis
Gastrointestinal (GI) diseases, and in particular those caused by bacterial infections, are a
major cause of morbidity and mortality worldwide. Treatment is becoming increasingly …

Research progress in enzymatically cross-linked hydrogels as injectable systems for bioprinting and tissue engineering

R Naranjo-Alcazar, S Bendix, T Groth, G Gallego Ferrer - Gels, 2023 - mdpi.com
Hydrogels have been developed for different biomedical applications such as in vitro culture
platforms, drug delivery, bioprinting and tissue engineering. Enzymatic cross-linking has …