Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant
primary brain tumors diagnosed in patients younger than 50, constituting an important cause …

Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …

The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are
poorly understood. Here we define myeloid cellular states in gliomas by longitudinal single …

Abstract The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate
dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation …

Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent
technological advances, new insights into the molecular mechanisms underlying glioma …

Metabolic reprogramming has become a key focus for both immunologists and cancer
biologists, with exciting advances providing new insights into the mechanisms underlying …

IDH1 mutations are common in low-grade gliomas and secondary glioblastomas and cause
overproduction of (R)-2HG.(R)-2HG modulates the activity of many enzymes, including some …

During activation, T cells undergo metabolic reprogramming, which imprints distinct
functional fates. We determined that on PD-1 ligation, activated T cells are unable to engage …

Mitochondria are dynamic organelles that have essential metabolic activity and are
regarded as signalling hubs with biosynthetic, bioenergetics and signalling functions that …

Antibiotics can have significant and long-lasting effects on the gastrointestinal tract
microbiota, reducing colonization resistance against pathogens including Clostridium …