Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa

PJ Rosenthal, V Asua, MD Conrad - Nature Reviews Microbiology, 2024 - nature.com
Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …

The emergence of artemisinin partial resistance in Africa: how do we respond?

PJ Rosenthal, V Asua, JA Bailey… - The Lancet Infectious …, 2024 - thelancet.com
Malaria remains one of the most important infectious diseases in the world, with the greatest
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …

Increasing prevalence of artemisinin-resistant HRP2-negative malaria in Eritrea

S Mihreteab, L Platon, A Berhane… - … England Journal of …, 2023 - Mass Medical Soc
Background Although the clinical efficacy of antimalarial artemisinin-based combination
therapies in Africa remains high, the recent emergence of partial resistance to artemisinin in …

Subcutaneous administration of a monoclonal antibody to prevent malaria

K Kayentao, A Ongoiba, AC Preston… - … England Journal of …, 2024 - Mass Medical Soc
Background Subcutaneous administration of the monoclonal antibody L9LS protected adults
against controlled Plasmodium falciparum infection in a phase 1 trial. Whether a monoclonal …

Artemisinin-resistant malaria

NJ White, K Chotivanich - Clinical Microbiology Reviews, 2024 - journals.asm.org
The artemisinin antimalarials are the cornerstone of current malaria treatment. The
development of artemisinin resistance in Plasmodium falciparum poses a major threat to …

[КНИГА][B] World malaria report 2023

World Health Organization - 2023 - books.google.com
Page 1 World malaria וייוייו report 2023 wwwwww World Health Organization Page 2 World
malaria report 2023 ISBN 978-92-4-008617-3 (electronic version) ISBN 978-92-4-008618-0 …

Emergence of Plasmodium falciparum strains with artemisinin partial resistance in East Africa and the Horn of Africa: is there a need to panic?

A Assefa, AA Fola, G Tasew - Malaria Journal, 2024 - Springer
The emergence and spread of artemisinin partial resistance in East and Horn of Africa is
alarming. However, artemisinin-based combination therapy (ACT) generally remains …

Disruption of Plasmodium falciparum kinetochore proteins destabilises the nexus between the centrosome equivalent and the mitotic apparatus

J Li, GJ Shami, B Liffner, E Cho, F Braet… - Nature …, 2024 - nature.com
Plasmodium falciparum is the causative agent of malaria and remains a pathogen of global
importance. Asexual blood stage replication, via a process called schizogony, is an …

Country wide surveillance reveals prevalent artemisinin partial resistance mutations with evidence for multiple origins and expansion of high level sulfadoxine …

JJ Juliano, DJ Giesbrecht, A Simkin, AA Fola… - MedRxiv, 2023 - pmc.ncbi.nlm.nih.gov
Background: Emergence of artemisinin partial resistance (ART-R) in Plasmodium falciparum
is a growing threat to the efficacy of artemisinin combination therapies (ACT) and the efforts …

Treatment Failure in a UK Malaria Patient Harboring Genetically Variant Plasmodium falciparum From Uganda With Reduced In Vitro Susceptibility to Artemisinin and …

DA van Schalkwyk, S Pratt, D Nolder… - Clinical Infectious …, 2024 - academic.oup.com
Background Recent cases of clinical failure in malaria patients in the United Kingdom (UK)
treated with artemether-lumefantrine have implications for malaria chemotherapy worldwide …