Apoptosis is a form of programmed cell death that is regulated by the balance between
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …

Apoptotic cell death inhibits oncogenesis at multiple stages, ranging from transformation to
metastasis. Consequently, in order for cancer to develop and progress, apoptosis must be …

Defects in apoptotic cell death can promote cancer and impair responses of malignant cells
to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by kee** the cell …

Intrinsic apoptosis is controlled by the BCL-2 family of proteins but the complexity of intra-
family interactions makes it challenging to predict cell fate via standard molecular biology …

Chronic lymphocytic leukemia (CLL), an incurable malignancy of mature B lymphocytes,
involves blood, bone marrow, and secondary lymphoid organs such as the lymph nodes …

The approval of venetoclax, a 'BH3-mimetic'antagonist of the BCL-2 anti-apoptotic protein,
for chronic lymphocytic leukemia represents a major milestone in translational apoptosis …

Background Proteins of the BCL-2 family regulate clonal selection and survival of
lymphocytes, and are frequently overexpressed in lymphomas. Navitoclax is a targeted high …

Apoptosis has been established as a mechanism of anti-cancer defense. Members of the
BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found …

Cancer is a daunting global problem confronting the world's population. The most frequent
therapeutic approaches include surgery, chemotherapy, radiotherapy, and more recently …

Chronic lymphocytic leukaemia (CLL) has several unique features that distinguish it from
other cancers. Most CLL tumour cells are inert and arrested in G0/G1 of the cell cycle and …