Toward explainable artificial intelligence for precision pathology

F Klauschen, J Dippel, P Keyl… - Annual Review of …, 2024 - annualreviews.org
The rapid development of precision medicine in recent years has started to challenge
diagnostic pathology with respect to its ability to analyze histological images and …

Combining machine learning and computational chemistry for predictive insights into chemical systems

JA Keith, V Vassilev-Galindo, B Cheng… - Chemical …, 2021 - ACS Publications
Machine learning models are poised to make a transformative impact on chemical sciences
by dramatically accelerating computational algorithms and amplifying insights available from …

A unifying review of deep and shallow anomaly detection

L Ruff, JR Kauffmann, RA Vandermeulen… - Proceedings of the …, 2021 - ieeexplore.ieee.org
Deep learning approaches to anomaly detection (AD) have recently improved the state of
the art in detection performance on complex data sets, such as large collections of images or …

AI-based pathology predicts origins for cancers of unknown primary

MY Lu, TY Chen, DFK Williamson, M Zhao, M Shady… - Nature, 2021 - nature.com
Cancer of unknown primary (CUP) origin is an enigmatic group of diagnoses in which the
primary anatomical site of tumour origin cannot be determined,. This poses a considerable …

DNA methylation profiling: an emerging paradigm for cancer diagnosis

A Papanicolau-Sengos, K Aldape - Annual Review of Pathology …, 2022 - annualreviews.org
Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …

Designing deep learning studies in cancer diagnostics

A Kleppe, OJ Skrede, S De Raedt, K Liestøl… - Nature Reviews …, 2021 - nature.com
The number of publications on deep learning for cancer diagnostics is rapidly increasing,
and systems are frequently claimed to perform comparable with or better than clinicians …

Exploring chemical compound space with quantum-based machine learning

OA von Lilienfeld, KR Müller… - Nature Reviews Chemistry, 2020 - nature.com
Rational design of compounds with specific properties requires understanding and fast
evaluation of molecular properties throughout chemical compound space—the huge set of …

[HTML][HTML] Pruning by explaining: A novel criterion for deep neural network pruning

SK Yeom, P Seegerer, S Lapuschkin, A Binder… - Pattern Recognition, 2021 - Elsevier
The success of convolutional neural networks (CNNs) in various applications is
accompanied by a significant increase in computation and parameter storage costs. Recent …

Prediction of DNA methylation-based tumor types from histopathology in central nervous system tumors with deep learning

DT Hoang, ED Shulman, R Turakulov, Z Abdullaev… - Nature Medicine, 2024 - nature.com
Precision in the diagnosis of diverse central nervous system (CNS) tumor types is crucial for
optimal treatment. DNA methylation profiles, which capture the methylation status of …

Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning

N Liang, B Li, Z Jia, C Wang, P Wu, T Zheng… - Nature biomedical …, 2021 - nature.com
The low abundance of circulating tumour DNA (ctDNA) in plasma samples makes the
analysis of ctDNA biomarkers for the detection or monitoring of early-stage cancers …