Mass spectrometry imaging in drug development
Drug discovery and development is a high-risk, expensive endeavor and it commonly takes
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …
Recent developments in multiplexing techniques for immunohistochemistry
Methods to detect immunolabeled molecules at increasingly higher resolutions, even when
present at low levels, are revolutionizing immunohistochemistry (IHC). These technologies …
present at low levels, are revolutionizing immunohistochemistry (IHC). These technologies …
Matrix-assisted laser desorption ionization imaging mass spectrometry: in situ molecular map**
Matrix-assisted laser desorption ionization imaging mass spectrometry (IMS) is a relatively
new imaging modality that allows map** of a wide range of biomolecules within a thin …
new imaging modality that allows map** of a wide range of biomolecules within a thin …
MALDI imaging mass spectrometry for direct tissue analysis: technological advancements and recent applications
B Balluff, C Schöne, H Höfler, A Walch - Histochemistry and cell biology, 2011 - Springer
Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
method that allows the investigation of the molecular content of tissues within its …
method that allows the investigation of the molecular content of tissues within its …
Conjugating immunoassays to mass spectrometry: Solutions to contemporary challenges in clinical diagnostics
KG Stevens, TL Pukala - TrAC Trends in Analytical Chemistry, 2020 - Elsevier
Developments in immunoassays and mass spectrometry have independently influenced
diagnostic technology. However, both techniques possess unique strengths and limitations …
diagnostic technology. However, both techniques possess unique strengths and limitations …
Mass spectrometry imaging in oncology drug discovery
Over the last decade mass spectrometry imaging (MSI) has been integrated in to many
areas of drug discovery and development. It can have significant impact in oncology drug …
areas of drug discovery and development. It can have significant impact in oncology drug …
Imaging of protein distribution in tissues using mass spectrometry: An interdisciplinary challenge
The recent development of mass spectrometry imaging (MSI) technology allowed to obtain
extremely detailed images of the spatial distribution of proteins in tissue at high spatial …
extremely detailed images of the spatial distribution of proteins in tissue at high spatial …
Tissue proteomics for the next decade? Towards a molecular dimension in histology
R Longuespée, M Fléron, C Pottier… - OMICS: A Journal of …, 2014 - liebertpub.com
The concept of tissues appeared more than 200 years ago, since textures and attendant
differences were described within the whole organism components. Instrumental …
differences were described within the whole organism components. Instrumental …
Advances in tissue section preparation for MALDI imaging MS
Enriched by a decade of remarkable developments, matrix-assisted laser desorption
ionization imaging mass spectrometry (MALDI IMS) has witnessed a phenomenal …
ionization imaging mass spectrometry (MALDI IMS) has witnessed a phenomenal …
Novel platforms of multiplexed immunofluorescence for study of paraffin tumor tissues
ER Parra - Journal of Cancer treatment and diagnosis, 2018 - cancertreatmentjournal.com
Multiplexed immunofluorescence (IF) methods to detect simultaneously different molecules
are revolutionizing immunohistochemistry (IHC) in the last years. These new technologies …
are revolutionizing immunohistochemistry (IHC) in the last years. These new technologies …